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Vladimir Gašić

Vladimir Gašić

Assistant Research Professor
Laboratory for molecular biomedicine

Institute for molecular genetics and genetical engineering (IMGGE),
University of Belgrade,

Vojvode Stepe 444a, 11042 Belgrade 152, Serbia
Mobile: +381 65 397 64 45
Phone: +381 11 397 64 45
E-mail: vlada.gasic@imgge.bg.ac.rs 

EDUCATION

2019 - PhD in Molecular Biology, Faculty of Biology (FB), UB (Thesis: Pharmacogenomic and Pharmacotranscriptomic Markers in Glucocorticoid Treatment of Pediatric Acute Lymphoblastic Leukemia: Molecular Mechanism of Action, Clinical and Population Aspects)

2015 -  Doctor of medicine MD , Faculty of Medicine (MF), University of Belgrade (UB)

RESEARCH EXPERIENCE

2019 - Research Associate at Laboratory for Molecular Biomedicine, IMGGE, UB
2018 – 2019 - Research Assistant at Laboratory for Molecular Biomedicine, IMGGE, UB
2015 – 2018 - Research Trainee at Laboratory for Molecular Biomedicine, IMGGE, UB

CAREER HISTORY

2020-2021 - Project „Nutrigenetics and status of vitamin D, zinc and selenium in Serbian population: are we ready for COVID-19?, financed by the „Pokreni se za nauku“ program - participant

2019 – 2023 - European Network for Innovative Diagnosis and Treatment of Chronic Neutropenias (EuNet-INNOCHRON, funded by The European Cooperation in Science and Technology, COST ACTION 18233) –participant of Young EuNET-INNOCHRON;

2021 - “Little school of DNAlogy”, grant from CPN

2015 – 2019 - Rare diseases: Molecular Pathophysiology, Diagnostic and Therapeutic Modalities and Social, Ethical and Legal Aspects, (MESTD RS, III41004) – participant;
2015 – 2016 - Strengthening the Research Potential of IMGGE through Reinforcement of Biomedical Science of Rare Diseases in Serbia – en route for innovation, SERBORDISinn”, funded by European Commission (EU-FP7-REGPOT, 316088, 2013-2016) – participant.

OTHER ACTIVITIES

2019 - 2021 – Teaching experience at PhD courses in Molecular Biology at the Faculty of Biology, University of Belgrade

RESEARCH INTEREST

The primary goal of my research is understanding of the pathophysiology and the genetics of severe and rare diseases, especially hematological malignancies. My current focus is on the pharmacogenomics of glucocorticoids in the therapy of childhood acute lymphoblastic leukemia (ALL) and adult myeloid leukemia (AML). My investigations are also related to molecular endocrinology and the role of microRNA and long non-coding RNA in diseases. I also intensively work on the effect of host genomics on the clinical presentation of COVID-19 disease.    

SELECTED PUBLICATIONS

  1. Gasic V, Zukic B, Stankovic B, Janic D, Dokmanovic L, Lazic J, Krstovski N, Dolzan V, Jazbec J, Pavlovic S, Kotur N. Pharmacogenomic markers of glucocorticoid response in the initial phase of remission induction therapy in childhood acute lymphoblastic leukemia. Radiol Oncol. 2018; Sep 11;52(3):296-306. doi: 10.2478/raon-2018-0034.
  2. Pavlovic S, Kotur N, Stankovic B, Zukic B, Gasic V, Dokmanovic L. Pharmacogenomic and Pharmacotranscriptomic Profiling of Childhood Acute Lymphoblastic Leukemia: Paving the Way to Personalized Treatment. Genes (Basel). 2019 Mar 1;10(3). pii: E191. doi: 10.3390/genes10030191.
  3. V Skodric Trifunovic, I Buha, D Jovanovic, V Vucinic, M Stjepanovic, V Spasovski, M Vreca, A Skakic, V Gasic, M Andjelkovic and S Pavlovic. Variants in VDR and NRAMP genes as susceptibility factors for tuberculosis in the population of Serbia. Genetika. 2015; Vol 47, No. 3, 1021-1028.
  4. Jordovic J, Bojovic K, Simonovic-Babic J, Gasic V, Kotur N, Zukic B, Vukovic M, Pavlovic S, Lazarevic I, Bekic I, Nikolic N, Urosevic A, Mitrovic N, Delic D. Significance of UGT1A1*28  polymorphism in patients with advanced liver injury caused by chronic hepatitis c. J Med Biochem 2019 Mar 1;38(1):45-52. doi: 10.2478/jomb-2018-0015.
  5. Vukovic M, Radlovic N, Lekovic Z, Vucicevic K, Maric N, Kotur N, Gasic V, Ugrin M, Stojiljkovic M, Dokmanovic L, Zukic B, Pavlovic S. UGT1A1 (TA)n promoter genotype: diagnostic and population pharmacogenetic marker in Serbia. Balkan Journal of Medical Genetics 2018 Oct 29;21(1):59-68. doi: 10.2478/bjmg-2018-0012.
  1. Bojović K, Stanković B, Kotur N, Krstić-Milošević D, Gašić V, Pavlović S, Zukić B, Ignjatović Đ. Genetic predictors of celiac disease, lactose intolerance, and vitamin D function and presence of peptide morphins in urine of children with neurodevelopmental disorders. Nutr Neurosci. 2019 Jan;22(1):40-50. doi: 10.1080/1028415X.2017.1352121
  1. V. Gasic, B. Stankovic, B. Zukic, D. Janic, L. Dokmanovic, N. Krstovski, J. Lazic, G. Milosevic, M. Lucafò, G. Stocco, G. Decorti, S. Pavlovic, and N. Kotur, “Expression Pattern of Long Non-Coding RNA Growth Arrest-Specific 5 in the Remission Induction Therapy in Childhood Acute Lymphoblastic Leukemia” J. Med. Biochem. 2019 May 11;38(3):292-298. doi: 10.2478/jomb-2018-0038.
  2.  Pavlovic S, Ugrin M, Micic S, Gasic V, Dimitrijevic J and Barteczko U. Using Genetics for Enhancement (Liberal Eugenics) (2018) in Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies, ed. by Sorin Hostiuc. Academic Press Elsevier Inc. London, UK, p. 335-367 ISBN 978-0-12-813764-2
  1. Jordovic J, Simonovic-Babic J, Gasic V, Kotur N, Zukic B, Pavlovic S, Lazarevic I, Karalic D, Katanic N, Nikolic N, Urosevic A, Nestorov J, Delic D, Bojovic K. IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury. J Infect Dev Countries 2019; 13(6):526-535. doi:10.3855/jidc.11351
  1. Stankovic B, Kotur N, Gasic V, Klaassen K, Ristivojevic B, Stojiljkovic M, Pavlovic S, Zukic B. Pharmacogenomics landscape of COVID-19 therapy response in Serbian population and comparison with worldwide populations. Journal of Medical Biochemistry (2020);39(4),:488-499. Doi: 10.5114/aoms.2020.96537.
  1. Klaassen, K., Stankovic, B., Zukic, B., Kotur, N., Gasic, V., Pavlovic, S., Stojiljkovic, M. Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infection. Infect Genet Evol. 2020 Aug 7;84:104498. doi: 10.1016/j.meegid.2020.104498.
  1. Doknic M, Gasic V, Stojanovic M, Pavlovic S, Marinkovic S, Miljic D, Pekic S, Manojlovic-Gacic E, Damjanovic D,  Soldatovic I, Petakov M. Hypopituitarism in five PROP1 mutation siblings - Long-lasting natural course and the effects of growth hormone replacement introduction in middle adulthood. Pituitary. 2020 Aug;23(4):400-408. doi: 10.1007/s11102-020-01049-9.
  2. Zukic B, Andjelkovic M, Gasic V, Grubin J, Pavlovic S, Djeric D. Genetic basis of Otosclerosis.  Srpski arhiv za celokupno lekarstvo 2020. DOI: 10.2298/SARH200306026Z
  3. Kotur N, Lazic J, Ristivojevic B, Stankovic B, Gasic V, Dokmanovic L, Krstovski N, Milosevic G, Janic D, Zukic B, Pavlovic S. Pharmacogenomic Markers of Methotrexate Response in the Consolidation Phase of Pediatric Acute Lymphoblastic Leukemia Treatment. Genes (Basel) 2020 pr 24;11(4). pii: E468. doi: 10.3390/genes11040468.
  1. Pavlovic S, Kotur N, Stankovic B, Gasic V, Lucafo M, Decorti G, Zukic B. Clinical application of thiopurine pharmacogenomics in pediatrics. Curr Drug Metab. 2020;21(1):53-62. doi: 10.2174/1389200221666200303113456.
  1. Marina Mihaljevic, Dusanka Franic, Ivan Soldatovic, Iva Lukic, Sanja Andric Petrovic, Tijana Mirjanic, Biljana Stankovic, Branka Zukic, Katarina Zeljic, Vladimir Gasic, Ivana Novakovic, Sonja Pavlovic, Miroslav Adzic, Nadja P Maric. The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls. Psychoneuroendocrinology 2021 Jun;128:105205. Epub 2021 Mar 23.https://doi.org/10.1016/j.psyneuen.2021.105205
  2. Nikola Kotur, Anita Skakic, Kristel Klaassen, Vladimir Gasic, Branka Zukic, Vesna SkodricTrifunovic2, Mihailo Stjepanovic, Zorica Zivkovic, Olivera Ostojic, Goran Stevanovic, Lidija Lavadinovic, Sonja Pavlovic, Biljana Stankovic. Association of vitamin D, zinc and selenium related nutrigenetic markers with COVID-19 disease severity Frontiers in Nutrition 8:689419. doi: 10.3389/fnut.2021.689419
  3. Vladimir Gasic, Djordje Pavlovic, Biljana Stankovic, Nikola Kotur, Branka Zukic and Sonja Pavlovic. Pharmacogenomics and Pharmacotranscriptomics of Glucocorticoids in Pediatric Acute Lymphoblastic Leukemia. In Corticosteroids. Ed Celso Pereira. 2021. IntechOpen Rijeka. 2021 DOI: http://dx.doi.org/10.5772/intechopen.98887
  4. Biljana Stankovic , Nikola Kotur, Gordana Nikcevic, Vladimir Gasic, Branka Zukic, Sonja Pavlovic. Machine Learning Modeling from Omics Data as Prospective Tool for Improvement of Inflammatory Bowel Disease Diagnosis and Clinical Classifications. Genes 2021, 12, 1438. https://doi.org/10.3390/genes12091438
  5. Pavlovic D, Tosic N, Zukic B, Pravdic Z, Vukovic NS, Pavlovic S, Gasic V. Expression Profiles of Long Non-Coding RNA GAS5 and MicroRNA-222 in Younger AML Patients. Diagnostics. 2022; 12(1):86. https://doi.org/10.3390/diagnostics12010086

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